Sex Differences in Renal Function: Participation of Gonadal Hormones and Prolactin

Kidney pathophysiology is influenced by gender. Evidence suggests that kidney damage more severe in males than females and sexual hormones contribute to this. Elevated prolactin concentration common renal impairment patients associated with an unfavorable prognosis. However, PRL involved the osmoregulatory process promotes endothelial proliferation, dilatation, permeability blood vessels. Several proteinases cleavage its structure, forming vasoinhibins. These fragments have antagonistic effects on endothelium might be dysfunction, but role kidneys has not been enough investigated. Therefore, purpose of this review describe influence dimorphism gonadal damage, emphasizing hormone products,